Accelerated blood clearance of PEGylated liposomes after repeated injection
نویسندگان
چکیده
منابع مشابه
The accelerated clearance on repeated injection of pegylated liposomes in rats: laboratory and histopathological study.
PEGylated liposomes which have a long-circulating property have been expected as promising drug carriers in the DDS field. For clinical setting, the multiple injection of the liposomes should not be negligible. Limited number of data is available on the influence of multiple injection on their pharmacokinet ics and the patients. In this study, the effect of repeated injection of PEGylated lipos...
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Surface modification of nanocarriers with amphiphilic polymer polyethylene glycol (PEG), known as PEGylation, is regarded as a major breakthrough in the application of nanocarriers. However, PEGylated nanocarriers (including liposomes and polymeric nanoparticles) induce what is referred to as the "accelerated blood clearance (ABC) phenomenon" upon repeated injection and consequently they lose t...
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Previously, we showed that long-circulating polyethylene glycol (PEG)-liposomes are cleared rapidly from the circulation when injected repeatedly in the same animal. In this article, we describe the effects of PEG-coating, the circulation time, the lipid dose, and the presence of encapsulated doxorubicin on the pharmacokinetics upon repeated injection in rats. Furthermore, the role of liver and...
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Sterically stabilized liposomes are considered promising carriers of therapeutic agents because they can facilitate controlled release of the drugs, thereby reducing drug-related toxicity and/or targeted delivery of drugs. Herein, we studied the pharmacokinetics and biodistribution of repeated injections of radiolabeled polyethyleneglycol (PEG) liposomes. Weekly injections of (99m)Tc-PEG liposo...
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BACKGROUND Sequential low-dose chemotherapy has received great attention for its unique advantages in attenuating multidrug resistance of tumor cells. Nevertheless, it runs the risk of producing new problems associated with the accelerated blood clearance phenomenon, especially with multiple injections of PEGylated liposomes. METHODS Liposomes were labeled with fluorescent phospholipids of 1,...
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ژورنال
عنوان ژورنال: Drug Delivery System
سال: 2004
ISSN: 1881-2732,0913-5006
DOI: 10.2745/dds.19.495